Researchers estimate that approximately one-third of adults worldwide have hypertension, also known as high blood pressure, which annually claims about 10 million lives globally. While certain factors like age, ethnicity, and existing health conditions contribute to hypertension, lifestyle changes such as weight loss, healthy eating, reduced salt intake, exercise, and quitting smoking can mitigate risks.
Recently, scientists from Queen Mary University of London identified over 100 new regions in the human genome and more than 2,000 genetic signals influencing blood pressure. Utilizing data from various sources, they identified novel genomic loci and genetic signals for blood pressure regulation.
By calculating polygenic risk scores, researchers found that individuals with the highest genetic risk for hypertension exhibit systolic blood pressure levels approximately 17 mmHg higher than those with the lowest genetic risk. Moreover, they have a seven-fold higher likelihood of developing high blood pressure.
Understanding the genetic impact on blood pressure could enhance polygenic risk scores, aiding in the prediction and prevention of hypertension. This knowledge allows for early interventions, potentially reducing the risk of future cardiovascular diseases.
Dr. Cheng-Han Chen, an interventional cardiologist, sees these findings as a promising step towards better hypertension treatment and prevention strategies. Identifying genetic markers associated with hypertension could facilitate targeted interventions for at-risk individuals, improving overall cardiovascular health outcomes.
